Injuries, such as falls, motor vehicle crashes, intimate partner violence and child maltreatment, are a major public health issue. Injuries cause almost 170,000 U.S. deaths each year, and are the leading cause of death for people age 1 to 44. Fifty million injuries per year take a physical and an economic toll, with each year's injuries leading to estimated lifetime costs of $406 billion in medical expenses and lost productivity. The World Health Organization estimates that by 2020, traffic-related injuries alone will be the third leading contributor to the global burden of disease and injury. Recognizing the social and economic burden of injury is critical to determine the appropriate level of intervention and investment into specific injury prevention activities.